BACTERIOPHAGE POLYVALENT AGAINST SALMONELLIOS - 20 ml 4 pcs glass bottles

1 mL of drinking solution comprises sterile, purified phage lysate filtrate active against salmonellosis pathogens such as Salmonella Typhimurium, Salmonella Newpon, Salmonella Enteritidis, Salmonella Moscow, Salmonella Paratyphi B, Salmonella Agama, and Salmonella Java. Phage titers are more than 1 × 10⁶ CFU/mL. 

Usage Instructions

Salmonellosis Treatment and Prevention 

Treatment of patients of any age and risk category with acute diarrhea (gastritis, gastroenteritis, gastro-enterocolitis, enteritis, enterocolitis, and colitis) and salmonellosis; 

Sanitation of Convalescents (bacteremia)

Salmonella bacteriophage is used to prevent disease during seasonal outbreaks, for children in preschool educational institutions and their educators, schools, and vacationers in summer camps. 

Salmonellosis Treatment and Prevention Using a Polyvalent Bacteriophage

This is a tried-and-true cure that is safe to use on newborns, throughout pregnancy, and during nursing. 

Bacteriophages

"Bacteria" and "phegos" [devouring] are viruses that swallow, eat, and kill bacteria; that is, they are bacteria's natural hosts. F. D'Herell, a French scientist, coined the term "bacteriophages" in 1917 to describe organisms capable of passing through bacterial filters and dissolving. They feature a more rounded or hexagonal head with a diameter of 45-140 nm and a tail with a length of 100-200 nm. Protein is used to make the shells of the head and tail. It has DNA or RNA in its head. 

The Mechanism of Action of Bacteriophage

Special elements of the phage, located in the form of legs in the tail, bind to the surface of bacteria. The next step does not occur until the bacteriophage is firmly attached to the surface of the bacteria.

The bacteriophage's genetic material is delivered into the bacterium's body after a strong binding of the bacteriophage (adsorption). It accomplishes this by utilizing an aggressive enzyme to pierce the bacterial membrane, which functions like a syringe owing to the phage's shape. 

The initial stage in the synthesis of new phages is the formation of genetic material into protein shells in the shape of an icosahedron. Other proteins required for the phage's survival also appear. The number of new phages within the bacterium explodes. A new generation is prepared to emerge from the bacterial cell. 

After penetrating, the phages destroy the bacterial wall, and the bacterium dies.

VS Antibiotic Polyvalent Bacteriophage Against Salmonellosis 

1. Zueva L.P., Aslanov B.I., Akimkin V.G. A modern view on the role of bacteriophages in the evolution of hospital strains and the prevention of healthcare-associated infections. Journal of Microbiology, Epidemiology and Immunobiology. 2014; (3): 100-7.

2. Domingo-Calap R., Delgado-Martínez J. Bacteriophages: protagonists of a post-antibiotic era. Antibiotics (Basel).2018; 7(3): 66.  https://doi.org/10.3390/antibiotics7030066 

As a result of the indiscriminate use of antibiotics, bacterial resistance to them is increasing day by day.

The use of bacteriophage, a natural combination of bacteria against salmonellosis, is the key to a highly effective therapy in the prevention and treatment of infection. 

The results of a scientific study comparing the effects of Salmonella bacteriophage and antibiotic treatment on the duration of Salmonella carriage and bacterial transmission. 

I.M. Moscow State Medical University named after Sechenev. 

1. As a result of treatment with bacteriophage, compared to fluoroquinolone antibiotics, the duration of transmission of salmonella bacteria was reduced by 1.5–2.5 times.

2. As a result of treatment with bacteriophage, compared to fluoroquinolone antibiotics, the duration of salmonella transmission was reduced by 6- 20 times.

Such a result has important clinical and epidemiological significance and indicates the high efficiency of the bacteriophage.

 Akimkin V.G. Sovremennye aspects of epidemiology and prevention of nosocomial salmonella. Medicinsky Soviet. Hospital therapy, 2013, 5-6: Chast 1: 33-39. 

Administration.

An important condition for effective treatment with phage is to determine the sensitivity of the pathogen to this phage (detection of the sensitivity of the disease-causing bacterium isolated from the patient to this phage). The use of phage in the initial phase of the disease is highly effective. The drug is intended for oral and rectal administration. For treatment, the drug is taken 3 times a day, 1 hour before meals. The duration is 7–10 days from the first day of the disease. In the case of salmonellosis, which is characterized by mild colitis syndrome, and during the recovery period, it is recommended to take 2 times the age-dependent amount of phage, and after emptying the intestine, it is recommended to administer a single dose of age-specific phage in the form of a rectal enema.

Side Effects

The drug is not toxic. No side effects have been identified. 

The drug should not be taken

The drug should not be used in cases of hypersensitivity to any of its components. 

Special Instructions

Pregnancy and nursing. Bacteriophage can be utilized during pregnancy and nursing at the discretion of the doctor. The drug should be shaken before use.

The medicine cannot be used in the presence of turbidity. The drug maintains a nutrient environment in which bacteria can develop in the environment. Therefore, the following rules should be observed when opening the vial, when taking and storing the drug: 1. Wash your hands thoroughly; 2. Before opening the vial cap, it should be treated with an alcohol solution; 3. It is necessary to open the lid without removing the cork and draw the medicine from the opened vial with a sterile syringe (by piercing the cork); 4. When opening the vial, if the cork comes out with the cap, it is impossible to leave the vial open; 5. The opened vial should be stored in the refrigerator. Subject to storage conditions, the drug can be used within 24 hours after opening the vial.

Dispensing at pharmacies. Without a prescription.